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Lergigan Theoclate works by stopping histamine from binding to its receptors in an area in the brain known as the vomiting centre. The vomiting centre is responsible for causing feelings of sickness and for the vomiting reflex. It is activated when it receives nerve messages from the vestibular apparatus in the middle ear. The vestibular apparatus provides constant feedback to the brain about the position of our body.
When something disturbs the vestibular apparatus, such as movements of the head when travelling by boat or car, nerve signals are sent from the vestibular apparatus to the vomiting centre. This can cause the symptoms of motion sickness, such as nausea, dizziness or spinning sensations vertigo and vomiting. By blocking the histamine receptors in the vomiting centre, Lergigan Theoclate prevents disturbances in the middle ear from activating the vomiting centre.
Lergigan – Promethazine hydrochloride uses, dose and side effects
Lergigan is is a histamine H1 antagonist that can be used for it's ability to induce sedation, reduce pain, and treat allergic reactions. Lergigan's effects generally last h but can last up to 12h. Patients should be counselled regarding CNS and respiratory depression, reduce seizure threshold, and bone marrow depression. Lergigan Theoclate Tablets are an anti-emetic anti-sickness drug which helps to prevent, and treat nausea and vomiting, including travel sickness, and vertigo.
Lergigan Theoclate contains promethazine which belongs to a group of medicines called phenothiazines. Your doctor may prescribe this medicine for giddiness or light-headedness vertigo , or for sickness after an operation, and in such cases the tablets should be taken as instructed by your doctor. Lergigan is a an antagonist of histamine H1, post-synaptic mesolimbic dopamine, alpha adrenergic, muscarinic, and NMDA receptors.
The antihistamine action is used to treat allergic reactions. Antagonism of muscarinic and NMDA receptors contribute to its use as a sleep aid, as well as for anxiety and tension. Antagonism of histamine H1, muscarinic, and dopamine receptors in the medullary vomiting center make promethazine useful in the treatment of nausea and vomiting.
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To prevent travel sickness on short journeys : Lergigan Theoclate should be taken at least one or two hours before travelling. Adults and children aged over 10 yearsshould take one tablet. Children aged 5 to 10 years should be given half a tablet. To prevent travel sickness onlong journeys : Lergigan Theoclate should be taken at bedtime each night during the journey, startingthe night before you travel.
Adults and childrenaged over 10 yearsshould take one tablet. To treat travel sickness :Adults and children over 10 years should take one tablet as soon as you feel sick, followed by a second tablet the same evening. Take a third tablet the following evening if necessary. Children aged 5 to 10 years should treated in the same way, but with half a tablet each time.
For sickness and vomiting due to other causes, and for treating vertigo : Adults and children aged over 10 years should take one tablet up to three times aday. Children aged 5 to 10 years should be given half a tablet up to three times a day. Alternativelyyou should follow the instructions given by your doctor. Medicines and their possible side effects can affect individual people in different ways.
The following are some of the side effects that are known to be associated with promethazine. Just because a side effect is stated here does not mean that all people using Lergigan Theoclate will experience that or any side effect. Patients experiencing an overdose of promethazine may present with mild central nervous system and cardiovascular depression, hypotension, respiratory depression, unconciousness, hyperreflexia, hypertonia, ataxia, athetosis, extensor-plantar reflexes, convulsions, dry mouth, flushing, gastrointestinal symptoms, and fixed, dilated pupils.
Lergigan Filmdragerad tablett 25 mg Burk, 30 tabletter
Treat overdoses with symptomatic and supportive treatment, which may include activated charcoal, sodium sulfate, magnesium sulfate, controlled ventilation, diazepam, intravenous fluids, vasopressors, norepinephrine, phenylephrine, anticholinergic antiparkinsonian agents, diphenhydramine, barbiturates, or oxygen. Lergigan Theoclate tablets can make some people feel drowsy, dizzy, confused or disorientated and this may reduce your ability to drive or operate machinery safely.
Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance. If your child is affected in this way they should avoid potentially hazardous activities such as riding bikes. You should not leave your child unattended after giving them this medicine.